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6 lip 2020 · As discussed earlier, the pro‐inflammatory mediators released by PAMP‐ and DAMP‐activated cells include prostaglandins which act on endothelial cells increasing local blood flow, on local nerves inducing pain and influence the function of leukocytes, including neutrophils.
24 mar 2017 · Researchers have discovered that the lungs play a far more complex role in mammalian bodies than we thought, with new evidence revealing that they don't just facilitate respiration - they also play a key role in blood production.
2 kwi 2020 · In this review and as members of the NIH/NHLBI-supported Progenitor Cell Translational Consortium, we discuss key aspects of lung repair and regeneration. We focus on the cellular compositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury, and new methods to study lung repair and regeneration.
2 kwi 2020 · A new methodology for lung regeneration is now under development through an integrated use of three components: (1) extended duration of lung support ex vivo (several days) by cross-circulation with a living host, (2) targeted treatment of the injured regions of the lung (from conducting airways to distal regions), with the preservation of the ...
2 lut 2019 · Alterations in cellular metabolism drive complex pathological events in the lung, including the shortening of cilia, the profibrotic activation of lung fibroblasts and macrophages, and the induction of both cell death and cellular senescence in the lung epithelium.
20 paź 2020 · In the pulmonary capillaries oxygen binds to haemoglobin in the blood red cells (erythrocytes). Haemoglobin greatly increases the capacity of blood to carry oxygen to the cells of the body—far greater than if oxygen were just dissolved in the plasma.
9 wrz 2019 · The lungs, previously thought to be sterile, are now known to harbor a unique microbiota and, additionally, to be influenced by microbial signals from distal body sites, such as the intestine.
