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17 maj 2017 · In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous DNA end joining (NHEJ) pathway. Defects in NHEJ result in sensitivity to...
17 maj 2017 · Mammalian non-homologous DNA end joining (NHEJ) is the primary pathway for the repair of DNA double-strand breaks (DSBs) throughout the cell cycle, including during S and G2 phases. NHEJ...
Illegitimate recombination (IR) is the exchange of genetic information by forma-tion of junctions between nonhomologous chromosome segments. IR is intimately associated with the process of nonhomologous end-joining (NHEJ) that is depend-ent on Ku, DNA ligase IV, and associated proteins.
As this end joining does not require a second homologous DNA duplex, it is of major importance in the G1 phase of the cell cycle where there is only a single copy of each chromosome. This article will focus on non-homologous end joining as a mechanism of DNA repair.
1 paź 2023 · We summarize findings from the recent cryo-EM structures of synaptic and presynaptic NHEJ complexes. Structures of DNA-PKcs coordinating with the other NHEJ factors suggest molecular mechanisms underlying its roles in bridging broken DNA ends and regulating DSB repair.
In eukaryotes, homologous recombination is restricted to late S or G2, whereas nonhomologous DNA end joining (NHEJ) can occur throughout the cell cycle and is the major pathway for the repair of double-strand breaks in multicellular eukaryotes.
Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. It is called "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homology directed repair (HDR), which requires a homologous sequence to guide repair.
