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HMP shunt atau jalur pentosa fosfat adalah jalur alternatif oksidasi glukosa yang menghasilkan NADPH dan pentosa seperti ribosa 5-P yang diperlukan untuk sintesis asam nukleat. Jalur ini terutama terjadi di hati, jaringan lemak, dan kelenjar untuk mensintesis asam lemak, kolesterol, dan hormon steroid yang membutuhkan NADPH.
The pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt or HMP shunt) is a metabolic pathway parallel to glycolysis. [1] It generates NADPH and pentoses (five-carbon sugars) as well as ribose 5-phosphate, a precursor for the synthesis of nucleotides. [1]
Hexose Monophosphate pathway or HMP Shunt is also called pentose phosphate pathway or phosphogluconate pathway. This is an alternative pathway to glycolysis and TCA Cycle for the oxidation of glucose. However, HMP shunt is more anabolic in nature, since it is concerned with the biosynthesis of NADPH and pentoses.
8 wrz 2022 · Electrolytes pathway (also known as the hexose monophosphate (HMP) shunt)) is an important physiological process that can occur in 2 phases: oxidative and nonoxidative.
11 lut 2023 · The (hexose monophosphate) HMP shunt, also known as the pentose phosphate pathway (PPP), is an important pathway in carbohydrate metabolism. It operates parallel to glycolysis and serves multiple purposes, including the production of NADPH, which is essential for various cellular processes, and the generation of ribose-5-phosphate, a precursor ...
HMP Shunt dalam eritrosit berguna sebagai penghasil suatu reduktor (NADPH). NADPH dapat mereduksi glutation yang telah mengalami oksidasi ( G-S-S-G ) menjadi glutation yang tereduksi (2 G-SH). Enzim yang mengkatalisis reaksi ini adalah glutation reduktase.
Siklus Krebs dan HMP Shunt merupakan lintasan metabolisme penting yang terjadi di dalam mitokondria sel. Siklus Krebs membentuk asam sitrat dari asetil-KoA dan menghasilkan energi berupa ATP dan NADH melalui oksidasi. HMP Shunt berperan sebagai jalur alternatif metabolisme glukosa dengan memproduksi NADPH.
