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22 lis 2011 · These levels used to be considered indicative of myocardial necrosis. However, with high-sensitivity troponin assays, circulating cTnT or cTnI can be found in the plasma as a result of transient ischemic or inflammatory myocardial injury.
The clinician must interpret cTn re-sults in the context of clinical history, ECG findings, and possibly cardiac imaging to establish the correct diag-nosis. A positive troponin in the setting of a low pretest probability for ACS may be suggestive but clearly is not indicative of a coronary event.
High sensitivity assays are the biomarkers of choice. All Bristol Trusts use high sensitivity Troponin T (hs Troponin T) and therefore this document only relates to hs Troponin T. hs Troponin T will start to rise 3-4 hours after injury and can stay elevated for up to 2 weeks.
Hs-TnI assays allows for more accurate and precise troponin results at very low levels, which permits for the use of an accelerated chest pain algorithm for rapid rule-out/rule-in of AMI. The new hs-TnI reporting protocol will involve reporting results in ng/L (compared to the previous μg/L).
What Is a High-Sensitivity Troponin Test? unprecedented analytic sensitivity and precision. Thus, a contemporary cTnI assay such as TnI-Ultra detects plasma cTn levels as low as 0.006 ng/mL with an assay range tha.
2 lis 2018 · HsTnT Algorithm. Interpretation of high-sensitivity Troponin T (hsTnT) at DUH. See also Maestro Care Tip Sheet. Last updated Nov. 2, 2018. ED Evaluation Using hsTnT: Symptoms < 3 hours. ED Evaluation Using hsTnT: Symptoms ≥ 3 hours. 3 Hour Troponin. Check 3-hr hsTnT & ECG 0-3h Delta < 7. 0-3h Delta ≥ 7. hsTnT(3h) ≥ 52. 0-3h Delta < 7.
High Sensitivity cTn 1. HScTn may have greater sensitivity but lower specificity for diagnosis of MI than conventional cTn in patients with chest pain. 2. In analysis of 17 studies, sensitivity 88% vs. 74%, however specificity 82% vs. 94%. 3. HScTn may detect more cases of ACS among low to intermediate risk patients with chest pain. 4.
