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14 lip 2022 · This primer discusses the use of high-sensitivity cardiac troponin (hs-cTn) testing in context of the 2021 multisociety guidelines for the evaluation and diagnosis of acute chest pain, with a notable focus on analytical aspects of the hs-cTn assays and their implications.
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make important recommendations that include the recognition of high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker, endorsement of 99th percentile upper reference limits to define myocardial injury, and the use of clinical decision
Hs-TnI assays allows for more accurate and precise troponin results at very low levels, which permits for the use of an accelerated chest pain algorithm for rapid rule-out/rule-in of AMI. The new hs-TnI reporting protocol will involve reporting results in ng/L (compared to the previous μg/L).
High sensitivity Troponin assays allow precise measurement at very low concentrations. High sensitivity assays are the biomarkers of choice. All Bristol Trusts use high sensitivity Troponin T (hs Troponin T) and therefore this document only relates to hs Troponin T.
22 lis 2011 · These levels used to be considered indicative of myocardial necrosis. However, with high-sensitivity troponin assays, circulating cTnT or cTnI can be found in the plasma as a result of transient ischemic or inflammatory myocardial injury.
High-sensitivity cardiac troponins are the preferred standard for establishing a biomarker diagnosis of acute myocardial infarction, allowing for more accurate detection and exclusion of myocardial injury.
We determined that there is sufficient clinical guidance on the use of cardiac troponin (cTn) testing from clinical practice groups. Thus, in this expert consensus docu-ment, we focused on clinical laboratory practice recom-mendations for high-sensitivity (hs)-cTn assays.
