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In recent years, much has been accomplished in clarifying its structure and its possible function in host immunity. This article summarizes current knowledge of CRP, with emphasis on clinical applications in pediatrics.
17 wrz 2018 · Multiple studies report higher mean/median CRP levels among infants delivered by VD and emergency cesarean delivery (CD) compared to elective CD.
We included cohort and cross-sectional studies evaluating the diagnostic accuracy of serum CRP levels for the detection of late-onset infection (occurring more than 72 hours after birth) in newborn infants.
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NICE guidance defines a consistent approach to management of early onset sepsis based on risk factors, clinical parameters and C-reactive protein (CRP) levels. Raised CRP levels in asymptomatic infants are not a good predictor of sepsis in isolation and can lead to investigations and prolonged courses of antibiotics.
High CRP levels are known to be associated with early-onset neonatal sepsis (EOS), which is a serious and potentially life-threatening disease in newborns.
CRP values were higher in EOS positive newborns (mean 27.0±32.7 vs. 17.9±19.0 mg/L). CRP values differed between preterm and term infants (mean 13.0±23.6 vs. 5.8±10.2 mg/L) despite comparable rates of EOS (19% and 18%, respectively).
