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C-REACTIVE PROTEIN (CRP), an acute-phase reactant, is nor mally present in trace amounts in the blood of healthy individ uals and increases in concentration in various inflammatory disorders and following tissue injury. Since its discovery in 1930, the clinical usefulness and limitations of CRP testing have been shown in many studies.
We compared 4,977 infants admitted to the study sites from 2012–2014 (Period 1: routine CRP use) with 5,135 infants admitted from 2018–2020 (Period 2: minimal CRP use) . Change in CRP use and pre-specified outcomes over time are shown in Figure 3 (available at www.jpeds.com ).
17 wrz 2018 · Multiple studies report higher mean/median CRP levels among infants delivered by VD and emergency cesarean delivery (CD) compared to elective CD.
High CRP levels are known to be associated with early-onset neonatal sepsis (EOS), which is a serious and potentially life-threatening disease in newborns.
We included cohort and cross-sectional studies evaluating the diagnostic accuracy of serum CRP levels for the detection of late-onset infection (occurring more than 72 hours after birth) in newborn infants.
NICE guidance defines a consistent approach to management of early onset sepsis based on risk factors, clinical parameters and C-reactive protein (CRP) levels. Raised CRP levels in asymptomatic infants are not a good predictor of sepsis in isolation and can lead to investigations and prolonged courses of antibiotics.
1 paź 1998 · Serial CRP levels are useful in the diagnostic evaluation of neonates with suspected infection. Two CRP levels <1 mg/dL obtained 24 hours apart, 8 to 48 hours after presentation, indicate that bacterial infection is unlikely. The sensitivity of a normal CRP at the initial evaluation is not sufficient to justify withholding antibiotic therapy.
