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17 cze 2022 · The Governing Board of the European Association for the Study of the Liver (EASL) selected a panel of experts to prepare these Clinical Practice Guideline (CPGs) with the purpose of providing the best available evidence on diagnosis and management of hepatic encephalopathy (HE).
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19 wrz 2024 · Treatment includes determining the appropriate setting for care, correcting any predisposing conditions (particularly dehydration or infection), and medications such as lactulose. Restricting dietary protein is not recommended.
Management includes early diagnosis and prompt treatment of precipitating factors (infection, gastrointestinal bleeding, electrolyte disturbances, hepatocellular carcinoma, dehydration, hypotension, and use of benzodiazepines, psychoactive drugs, and/or alcohol).
6 sie 2024 · Hepatic encephalopathy is a neuropsychiatric syndrome caused by acute or chronic advanced hepatic insufficiency. Symptoms vary in severity from a mild alteration in mental state to coma but are often reversible with treatment.
The GDG considered that the current standard treatment of an episode of acute hepatic encephalopathy is directed at reducing the production and absorption of gut-derived neurotoxins, particularly ammonia, mainly through bowel cleansing, and the use of non-absorbable disaccharides, such as lactulose.
After a brief overview of HE characteristics and pathophysiology, this review explores the current accepted treatments for this debilitating complication of cirrhosis. This is followed by an overview of the novel available therapies and a brief focus on future treatment modalities for HE. Keywords. Altered Mental Status. Ammonia.
The different conventional and emerging therapeutic options available to date are detailed in the manuscript. We have elaborated all the data available in the literature about the use of fecal microbiota transplant in the treatment of HE. INTRODUCTION.
