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It is not necessary to heat-treat every sample that tests negative, but if heartworm infection is suspected and the test result is negative, HPT can help ensure an appropriate diagnosis. Antigen testing of a heat-treated sample cannot distinguish between dead and living worms.
In the case of diagnostic testing methods that rely on soluble antigen for detection (eg, enzyme-linked immunosorbent assay, lateral flow assays), antigen bound in an immune complex may not be available for detection, leading to an NAD result despite the presence of antigen in the test sample.
Using heat treatment for immune-complex dissociation in challenging heartworm cases. Dirofilaria immitis infections are usually diagnosed based on history, physical examination, and laboratory findings. One of the key components in the diagnosis is the presence of heartworm antigen circulating in the blood of the infected patient.
9 sie 2022 · Ideally, microfilaria testing (modified Knott test, Millipore filter, direct smear, or microhematocrit technique) is performed along with antigen testing to confirm a positive antigen test result or help detect a false-negative result.
A positive antigen test result should always be confirmed before treatment is pursued. The antigen-negative (NAD), microfilaria-positive dog presents several possibilities: Patient with only 1 or 2 female heartworms whose antigen levels are not detectable with patient-side test; Light infection, immature worms
6 sty 2024 · Heat treatment is an immune complex dissociation technique used to enhance antigen detection. Only a few studies have reported the benefits of heat treatment in nationwide surveys.
Access the SNAP Heartworm RT Test product insert, accuracy data, sample preparation, results interpretation information and more. Find out which diseases have been confirmed in your neighborhood . IDEXX Test Promise
