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1 sty 2024 · During V(D)J recombination, the RSS ends are directly ligated together by the core C-NHEJ components to generate the RSS joins (sometimes referred to as ‘signal join’) of V(D)J recombination. In contrast, the hairpin coding ends require opening and processing before they can be joined.
1 sty 2015 · During lymphocyte development, the diverse repertoire of functional antigen receptors is created by the process of V(D)J recombination, in which various segments of an antigen receptor locus are brought together by several highly coordinated DNA cleavage and repair steps.
In this review, we summarize the major progress in mechanism studies of immunoglobulin V (D)J gene recombination and CSR as well as SHM, and their regulatory mechanisms.
7 lut 2020 · In this review, we summarize the major progress in mechanism studies of immunoglobulin V (D)J gene recombination and CSR as well as SHM, and their regulatory mechanisms.
28 kwi 2022 · Developing lymphocytes undergo a process of regulated DNA cleavage and subsequent repair, termed V (D)J recombination, to progress from progenitor cells to immature B or T cells. In this review, we focus on the mechanism as it occurs in B cells, however, many aspects can be applied to T cells.
29 maj 2024 · To identify key mechanistic elements for diffusional V (D)J recombination in Igk versus Igh, we assayed Vκ-to-J H and D-to-Jκ rearrangements in hybrid Igh–Igk loci generated by targeted...
21 lis 2014 · V(D)J recombination, the mechanism responsible for generating antigen receptor diversity, has the potential to generate aberrant DNA rearrangements in developing lymphocytes. Indeed, the recombinase has been implicated in several different kinds of errors leading to oncogenic transformation.
