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Confirmation of serological reactive tests may be done by a nucleic acid test (NAT) for detection of HCV RNA. Recent studies have also suggested that higher the anti-HCV antibody titer in patient's serum; more are the chances of it being true positive than false positive.
14 lip 2021 · After an acute HCV infection, HCV RNA could be detectable in serum within 2 weeks following exposure. On the other hand, anti-HCV could take about 8-12 weeks before results are positive....
HCV RNA binds to retinoic acid-inducible gene I, activating mitochondrial antiviral signaling (MAVS) proteins; double-stranded RNA bound to Toll-like receptor-3 induces signaling via TIR domain-containing adaptor inducing IFN-β (TRIF).
HCV core antigen assay: An assay to detect HCV core (p22) antigen, which has comparable clinical sensitivity to laboratory-based HCV RNA NAT assays, can be an alternative approach to diagnose HCV viraemic infection *. (conditional recommendation, moderate certainty of evidence).
