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Confirmation of serological reactive tests may be done by a nucleic acid test (NAT) for detection of HCV RNA. Recent studies have also suggested that higher the anti-HCV antibody titer in patient's serum; more are the chances of it being true positive than false positive.
Point-of-care (POC) HCV RNA assays: The use of HCV point-of-care (POC) RNA NAT assays can be an alternative approach to laboratory-based HCV RNA NAT assays to diagnose HCV viraemic infection (conditional recommendation, low/moderate certainty of evidence).
17 kwi 2024 · Acute hepatitis C is defined by any symptom of acute viral hepatitis plus either jaundice or elevated serum alanine aminotransferase (ALT) activity with the detection of HCV RNA, the anti-HCV antibody, or hepatitis C virus antigen(s). However, most patients with acute infection are asymptomatic.
12 paź 2018 · The non-detection of serum HCV RNA by qualitative PCR-based assays is defined as the viral clearance. However, even after achieving apparent viral clearance by the end of treatment, some individuals show recurrence. These individuals may have a low viral load that it is undetected by PCR methods.
2 mar 2017 · The sole presence of HCV RNA, but not antibodies, indicates acute HCV infection; a second test should be performed a few weeks later to show seroconversion, which proves acute HCV infection.
16 lis 2023 · Twenty-one (52.5%) donors were found to be HCV-RNA-positive, while 19 (47.5%) were HCV RNA negative (none received antiviral treatment). All but one seroconverted to anti-HCV.
A reflex test for serum specimens that are hepatitis C Virus (HCV) antibody screen-reactive for diagnosis of chronic hepatitis C. This test is appropriate for diagnosis of acute hepatitis C in high-risk or immunosuppressed individuals who may be negative for HCV antibodies.
