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Confirmation of serological reactive tests may be done by a nucleic acid test (NAT) for detection of HCV RNA. Recent studies have also suggested that higher the anti-HCV antibody titer in patient's serum; more are the chances of it being true positive than false positive.
Therefore, the range of clinically observed HCV RNA concentrations in serum is rarely below the lower range of the limit of quantification of quantitative assays, and most NAT assays (quantitative or qualitative) will capture the majority of viraemic infections as well as treatment failures.
ALL HCV ANTIBODY POSITIVE RESULTS REQUIRE SUPPLEMENTAL RNA TESTING . Since 2013, the US Centers for Disease Control and Prevention (CDC) recommends that all specimens that are HCV antibody reactive should be tested using a NAT to detect HCV RNA in order to confirm current HCV infection.
6 cze 2015 · HCV RNA in the serum is probably the earliest detectable marker of acute HCV infection, preceding the appearance of anti-HCV antibody by several weeks. CHC infection is defined as the presence of HCV RNA more than 6 mo. HCV RNA levels remain relatively stable over time in CHC patients.
9 wrz 2024 · Zhang et al. investigated the use of HCR in HCV RNA detection in an unconventional way, measuring the RNA as an inhibitor not as an initiator. An HCR system was used that included an initiator so that without target DNA the HCR would progress exponentially.
2 mar 2017 · Diagnostic tools include anti-HCV antibody testing, measurement of HCV RNA in the serum as well as genotyping, subtyping and analysis of resistance-associated substitutions (RASs).
30 kwi 2020 · We have developed a fully automated microfluidic RT-qPCR system for rapid quantitative detection of HCV RNA in human EDTA-plasma and serum, and the performance of the method was assessed.
