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Confirmation of serological reactive tests may be done by a nucleic acid test (NAT) for detection of HCV RNA. Recent studies have also suggested that higher the anti-HCV antibody titer in patient's serum; more are the chances of it being true positive than false positive.
- Detection of Viraemic HCV Infection to Guide Treatment – New ...
The new generation of quantitative and qualitative assays...
- Detection of Viraemic HCV Infection to Guide Treatment – New ...
Clinical care for patients with HCV-related liver disease has advanced considerably thanks to an enhanced understanding of the pathophysiology of the disease, as well as developments in diagnostic procedures and improvements in therapy and prevention.
The new generation of quantitative and qualitative assays for HCV RNA NAT assays have the same LoD, which is around 15 IU/mL. However, quantitative assays are a reproducible method to detect and quantify HCV RNA in plasma or serum.
30 kwi 2020 · We have developed a fully automated microfluidic RT-qPCR system for rapid quantitative detection of HCV RNA in human EDTA-plasma and serum, and the performance of the method was assessed.
15 sie 2019 · The quantitative HCV RNA test is checked before a patient starts treatment. For each patient, the result can be described as either a "high" viral load, which is usually >800,000 IU/L, or a "low" viral load, which is usually <800,000 IU/L.
Since 2013, the US Centers for Disease Control and Prevention (CDC) recommends that all specimens that are HCV antibody reactive should be tested using a NAT to detect HCV RNA in order to confirm current HCV infection.
A HCV RNA level below 25 IU/mL in serum or plasma 12 weeks after ending therapy is the therapeutic goal and indicates an SVR is achieved. Quantitative HCV RNA testing can be considered at the end of therapy and at 24 weeks or later after completion of antiviral therapy.
