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The speckled pattern in ANA (Antinuclear Antibody) testing is one of the most common and diagnostically significant patterns, characterized by its distinctive, fine or coarse speckled appearance under a fluorescence microscope.
5 sty 2022 · The International Consensus on ANA Patterns (ICAP) classifies 30 relevant patterns (AC-0 to AC-29). AC-4 (fine speckled nuclear pattern) is associated to anti-SS-A/Ro, anti-SS-B/La, and...
21 lut 2024 · ANA patterns can be associated with different autoimmune conditions. These patterns can range from homogenous to speckled, and each carries its own significance in terms of potential autoimmune conditions. Below is a summary of the patterns discussed: Homogenous pattern: Also called nuclear homogenous.
1 sie 2020 · ICAP-oriented IB detected 515 antibody reactivities vs. 457 of traditional anti-ENA in the nuclear speckled pattern group, 108 vs. 28 in the nucleolar pattern group, and 43 vs. 34 in the cytoplasmic speckled pattern.
5 sty 2022 · Since the first ICAP Workshop, 30 different HEp-2 IFA patterns have been categorized into 4 major groups: negative (n = 1), nuclear (n = 15), cytoplasmic (n = 9), and mitotic patterns (n = 5) (2, 3, 5, 7, 8).
23 lis 2020 · The highest scores for clinical relevance were obtained for the centromere (AC-3) and homogeneous (AC-1) pattern, followed by the nuclear speckled (AC-2,4,5) and cytoplasmic reticular (AC-21) patterns.
17 sty 2019 · Scleroderma or systemic sclerosis: ANA pattern is most commonly speckled, followed by centromeric and less commonly nucleolar. Mixed connective tissue disease: ANA pattern is almost always...
