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27 maj 2021 · Alterations in nuclear DNA-encoded mitochondrial genes have confirmed the importance of mitochondrial metabolism in cancer, affecting mitochondrial reactive oxygen species production, redox state...
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28 paź 2009 · Moreover, mtDNA haplogroup H is a strong independent predictor of outcome during severe sepsis, conferring a over 2-fold increased chance of survival at 180 days compared with individuals with different haplogroups .
17 lip 2023 · Recovery after an abdominal hysterectomy can take up to 8 weeks, while vaginal or laparoscopic hysterectomy may have shorter recovery times. Long-term side effects can include hormonal...
Mitochondria function as modulators for regulating cellular metabolism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysregulation of mitochondria-encoded genes are associated with survival outcomes among cancer patients.
2 paź 2020 · Mean overall survival rate, relapse-free survival rate, and 5-year survival rate in the group with extended hysterectomy were higher compared to the group with total abdominal hysterectomy.
1 gru 2018 · In this review, we summarize the current knowledge of mtDNA alterations, with a specific focus on somatic changes, germline variants, haplogroups, large deletions, and mtDNA content changes associated with cancer susceptibility and prognosis. We also discuss the potential of mtDNA as biomarkers of cancer detection and targets of cancer treatment.
1 gru 2020 · Interestingly, in a small number of tumor types (adrenocortical carcinoma, chromophobe renal cell carcinoma, and low-grade glioma), low mtDNA content was associated with decreased survival rates.