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27 maj 2021 · Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two classes of cancer mtDNA variants can be identified: de novo mutations that act as ‘inducers’ of...
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Mitochondria function as modulators for regulating cellular metabolism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysregulation of mitochondria-encoded genes are associated with survival outcomes among cancer patients.
18 lut 2022 · Here, based on two independent datasets, we modelled an mtDNA mutation-cancer network by systematic integrative analysis including 37 cancer types to identify the mitochondrial variants found in common among them.
1 lip 2023 · Following this finding, mtDNA mutations were classified in two types of variants: 1) de novo mutations that act as “inducers” of carcinogenesis, and 2) functional variants, that act as carcinogenesis “adaptors” allowing cancer cells to adapt to and survive in different environments (Kopinski et al., 2021).
1 gru 2018 · In this review, we summarize the current knowledge of mtDNA alterations, with a specific focus on somatic changes, germline variants, haplogroups, large deletions, and mtDNA content changes associated with cancer susceptibility and prognosis. We also discuss the potential of mtDNA as biomarkers of cancer detection and targets of cancer treatment.
1 gru 2020 · Whether these results are influenced by the amount of immune or stromal infiltrate is unclear. Interestingly, in a small number of tumor types (adrenocortical carcinoma, chromophobe renal cell carcinoma, and low-grade glioma), low mtDNA content was associated with decreased survival rates.
Polymorphisms in mitochondrial DNA (mtDNA) are used to group individuals into haplogroups reflecting human global migration and are associated with multiple diseases, including cancer. Here, we evaluate the association between mtDNA haplogroup and risk of myelodysplastic syndromes (MDS).
