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H5N1 is an avian influenza virus that causes respiratory disease in birds and several land and sea mammals. The recent outbreak in the United States, including infection of dairy workers, has increased the concern around potential transmission and spread.
1 wrz 2023 · Highly pathogenic avian influenza (HPAI) strains like H5N1 have caused significant outbreaks in birds. Since 2003 to 14 July 2023, the World Health Organization (WHO) has documented 878 cases of HPAI H5N1 infection in humans and 458 (52.16%) fatalities in 23 countries.
The H5N1 virus is constantly evolving and could potentially become easily transmissible from person to person. If this occurs, it could be the start of a new influenza pandemic, as was the case with the 1918 and 2009 H1N1 pandemics.
25 paź 2024 · Following a series of key events between 2014 and 2020, a subgroup of the HPAI gs/gd H5N1 lineage (known as clade 2.3.4.4b) emerged and spread like wildfire. Since September 2021, the virus has spread globally, with the exception of Oceania (up to August 2024).
Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic (maintained in the population) in many bird populations, and also panzootic (affecting animals of many species over a wide area). [1]
Highly pathogenic influenza viruses of the H5N1 subtype have infected more than 600 people since 1997, resulting in the deaths of approximately 60% of those infected. Multiple studies have established the viral hemagglutinin (HA) surface glycoprotein as the major determinant of H5N1 virulence.
17 lut 2022 · WHO has published guidance on the clinical management of human infection with A(H5N1) as well as rapid advice guidelines on pharmacological management of humans infected with avian influenza A (H5N1) virus, which contains a chapter on ‘chemoprophylaxis of H5N1 infection’.