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Helicobacter pylori (H. pylori) is the main risk factor for gastric cancer, along with alcohol consumption and smoking. Other dietary habits associated with an increased risk of developing the disease are the consumption of salt-preserved foods and a low-fruit diet.
After up to 10 years of follow-up, 12.8% of the H. pylori cohort were diagnosed with cancer (p=0.002, figure 2), and in the regression analysis, there was a small but significant association between H. pylori and a subsequent diagnosis of cancer (HR: 1.11; 95% CI 1.04 to 1.18).
19 sie 2023 · H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally. We conducted a systematic review and meta-analysis to assess the global prevalence of GC in H. pylori-infected individuals.
17 maj 2023 · H. pylori induces chronic inflammation affecting the gastric epithelium, which can lead to DNA damage and the promotion of precancerous lesions. Disease manifestations associated with H. pylori are attributed to virulence factors with multiple activities, and its capacity to subvert host immunity.
2 lut 2023 · Here, we review and discuss the major pathogenetic mechanisms by which H. pylori infection contributes to the onset and development of gastric cancer. Keywords: inflammation; cytokines; ROS; virulence factors; CagA; genomic instability; MMR.
20 kwi 2023 · Helicobacter pylori infection causes chronic gastritis, which can progress to severe gastroduodenal pathologies, including peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid...
6 sty 2022 · Here we critically reflect on H. pylori infection and delineate what is currently known about the virulence and pathogenesis mechanisms of H. pylori. Helicobacter pylori is an organism associated with ulcer disease and gastric cancer.
