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Carcinogenetic mechanisms associated with H. pylori are based, on the one hand, on the onset of chronic inflammation and, on the other hand, on bacterial-specific virulence factors that can damage the DNA of gastric epithelial cells and promote genomic instability.
- Helicobacter pylori and Its Role in Gastric Cancer - PMC
H. pylori induces chronic inflammation affecting the gastric...
- Helicobacter pylori and Its Role in Gastric Cancer - PMC
3 lip 2023 · Binding of H. pylori to host cells and tissues is the first step in its bacterial pathogenesis. H. pylori attaches to gastric epithelial cells via its adhesin HopQ and engages specific cellular...
12 lip 2024 · Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment.
5 cze 2024 · Key points. Intratumoural bacteria interact with cancer cells and components of the tumour microenvironment in complex ways, which can either promote or suppress cancer. The effects depend on...
17 maj 2023 · H. pylori induces chronic inflammation affecting the gastric epithelium, which can lead to DNA damage and the promotion of precancerous lesions. Disease manifestations associated with H. pylori are attributed to virulence factors with multiple activities, and its capacity to subvert host immunity.
2 dni temu · Within the realm of GC research, Helicobacter pylori (H. pylori) has emerged as the gut microbe with the strongest association with this disease, ... Recent studies have demonstrated that certain bacteria can suppress cancer cells by promoting T-cell activation, and their absence or downregulation may in turn lead to cancer initiation. ...
21 kwi 2020 · Using a co-culture in vitro system in which different gastric cancer cell lines were exposed to H. pylori bacterium or H. pylori products, Kim et al. found that H. pylori infection of gastric epithelial cells leads to a decrease in mRNA levels of the MMR genes hMSH2 and hMLH1 (Kim et al. 2002).
