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Rough-endoplasmic reticulum - rER. The outer membrane of the rER is studded with ribosomes. This gives a basophilic staining to cytoplasm in H&E stains (due to the RNA content). The rER plays a major role in protein synthesis. It synthesises secretory proteins, and lysosomal enzymes.
- What is Histology: The Histology Guide
H&E staining. The most commonly used staining system is...
- What is Histology: The Histology Guide
H&E staining. The most commonly used staining system is called H&E (Haemotoxylin and Eosin). H&E contains the two dyes haemotoxylin and eosin. Eosin is an acidic dye: it is negatively charged (general formula for acidic dyes is: Na + dye-). It stains basic (or acidophilic) structures red or pink. This is also sometimes termed 'eosinophilic'.
8 sie 2023 · Function. The RER is associated with many roles in protein synthesis, which also include post-translational modifications, folding, and sorting. Membrane-bound ribosomes in the RER translate the mature mRNA transcript into amino acids that are attached to become polypeptides.
The ER occurs in two morphologically distinct forms: rough ER and smooth ER. The outer side (facing the cytosol) of the rough ER is studded with ribosomes that are the sites of protein synthesis. Under the electron microscope, the dense granular ribosomes gave the name “rough” ER.
12 mar 2021 · That has been the case with hepatocytic inclusions detected in H&E-stained preparations, which appeared to correspond to secretory proteins that, due to genetic mutations, were retained within the rough endoplasmic reticulum (RER) and were deficient in plasma.
Within the cytoplasm the rough endoplasmic reticulum (ER) is readily seen in cells that are secreting large amount of protein. Because the rough ER contains a high concentration of ribosomes, it will stain blue in H&E samples and contrast nicely with the pinkish cytoplasm.
The endoplasmic reticulum (ER) is a system of interconnected membranous sacs, channels, or cisternae in the cytoplasm. It has two subtypes: rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER). The RER is a ribbon-like structure surrounding the nucleus near the base of the cell.
