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  1. Proanthocyanidin-rich grape seed extract (GSE) was orally administered to 12 Japanese woman candidates with chloasma for 6 months between August 2001 and January 2002 and to 11 of these 12 for 5 months between March and July 2002.

  2. Grape seed extract. Grape seed extract contains proanthocyanidin, which is a powerful antioxidant. Although, there are no studies on the topical use of grape seed extract, but oral intake for 6 months has been found beneficial in patients with melasma in a study conducted by Yamakoshi, et al.

  3. Vitamin E, niacinamide, polypodium leucotomos, pycnogenol, grape seed extract, amino fruit acids, phytic acid, zinc, silymarin, Korean red ginseng powder, plant extracts, and parsley all have well-demonstrated evidence of antioxidant properties, and these substances have been studied in the context of skin hyperpigmentation.

  4. 15 lip 2024 · In the following sections, we will explore the role of grape seed extract in treating melasma, supported by scientific evidence, and discuss recommended dosages, usage methods, and alternative treatments. 2. The Role of Grape Seed Extract in Melasma Treatment. 2.

  5. 26 lip 2024 · Explore the potential of grapefruit seed extract and grape seed extract in treating melasma. Learn how they work, scientific studies, benefits, drawbacks, and alternatives. Plus, precautions and recommendations for use.

  6. 1 mar 2019 · The studied oral nutritional dietary supplement containing Pinus pinaster bark extract, Grape seed extract, vitamins and minerals is effective and well tolerated as a treatment option for mild to moderate facial melasma in combination with high SPF sunscreen.

  7. Yamakoshi et al. demonstrated the skin-lightening property of proanthocyanidin-rich grape seed extract in the treatment of melasma on Japanese women. Thus, most of these agents are used as over-the-counter adjuncts without much credible scientific evidence.