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Ganglioside GM1 is protective of the central nervous system and is used to study neurologic disorders.
12 mar 2015 · In this article, we review and speculate on various aspects of GM1 structure and function that are relevant to future studies of the physiological roles of endogenous gangliosides and the potential therapeutic effects of GM1 administration.
24 lut 2023 · Imagine-1 is a global, open-label, dose-escalation study of the AAVhu68 gene therapy PBGM01 delivered by intra-cisterna magna (ICM) injection in four cohorts of pediatric subjects with early and late infantile GM1 Gangliosidosis (GM1).
29 sty 2020 · Today, thanks to the myriad of studies and data reported in the literature, ever increasing information on how GM1 modulates some protein activity and the downstream cell signaling, acting on the cell biology, is becoming available. In this review, we report the state of art of the knowledge on ganglioside GM1. 2.
23 sty 2024 · GM1 gangliosidosis and GM2 gangliosidosis (Tay-Sachs and Sandhoff diseases) are lysosomal storage disorders caused by the accumulation of GM1 or GM2 gangliosides respectively, in the...
Many species of ganglioside GM1, differing for the sialic acid and ceramide content, have been characterized and their physico-chemical properties have been studied in detail since 1963. Scientists were immediately attracted to the GM1 molecule and ...
GM1, a ganglioside component of mammalian brains, is present mainly in neurons. GM1 is one of the best studied gangliosides, and our understanding of its properties is extensive.
