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22 lut 2022 · In non-vesicular trafficking, cytosolic GlcCer is transported by the phosphoinositol-four phosphate adapter protein 2 (FAPP2) from the cis Golgi to trans Golgi and then translocated by an ATP-dependent GlcCer flippase to the luminal leaflet, where the other steps for Gb3 synthesis take place.
Globoside is an intermediate in the synthesis of more complex structures of the globo series of glycosphingolipids such as the Forsmann antigen, the stage-specific embryonic antigen 4 and globo-H.
Galactocerebrosides are synthesized from ceramide and UDP-galactose and are found predominantly in neuronal cell membranes. By contrast, glucocerebrosides are found in membranes of other tissues, but only as intermediates of the synthesis of complex gangliosides, and thus at low levels.
Several groups have performed or are in the process of carrying out various stages of clinical trials with monovalent and polyvalent vaccines of Globo H because of its attractiveness as a therapeutic target [274–279].
Explore the diverse roles of globoside in cellular processes, disease pathogenesis, and therapeutic strategies. Learn about its structural composition, functional implications, and analytical techniques.
21 cze 2018 · Key technologies in the synthesis of gangliosides include α-selective sialylation and introduction of the ceramide moiety into the oligosaccharide chain. This chapter introduces two major strategies for ganglioside synthesis—the most commonly used strategy and the recently developed glucosylceramide cassette approach.
21 paź 2016 · Globoside (Gb4), a globo-series glycosphingolipid, is highly expressed during embryogenesis as well as organogenesis, including tooth development. We previously reported that Gb4 is dominantly...
