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Explore the diverse roles of globoside in cellular processes, disease pathogenesis, and therapeutic strategies. Learn about its structural composition, functional implications, and analytical techniques.
The anomeric structures of the remaining glycosidic bonds were assigned by glycosidase experiments [39,202] and NMR studies [74]. This established the whole carbohydrate structure of globoside: GalNAcβ1-3Galα1-4Galβ1-Glcβ1-Cer.
In a panel of structures isolated from the 2102Ep human teratocarcinoma cell line, the SSEA-3 antibody had the highest affinity for Galβ(1-3)GalNAcβ(1-3)Galα(1-4)Galβ(1-4)Glcβ(1)Cer [266]. This structure is also known as Gb5 [282], galactosyl-globoside, or globopentaosylceramide [263].
In human erythrocytes, glycolipids are antigenic determinants in different blood group phenotypes. These glycolipids are chemically based on the sequence Galα4Gal and comprise a system of P antigens (i.e., PK and LKE) and five phenotypes (i.e., P1, P2, P1K, P2K, p) (Naiki and Kato, 1979).
By analyzing the coding DNA sequence of the corresponding gene we show here for the first time that mutations capable of abolishing enzyme function are present in individuals with the P k phenotype.
Globoside is the most prominent neutral glycosphingolipid in human erythrocytes and is an essential structure of blood group P antigen . Globoside is synthesized from globotriaosylceramide (Gb3, P k antigen) by the action of β1,3-N-acetylgalactosaminyltransferase (β1,3GalNAc-T).
Globoside is an intermediate in the synthesis of more complex structures of the globo series of glycosphingolipids such as the Forsmann antigen, the stage-specific embryonic antigen 4 and globo-H.
