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Explore the diverse roles of globoside in cellular processes, disease pathogenesis, and therapeutic strategies. Learn about its structural composition, functional implications, and analytical techniques.
Globosides are multifunctional glycosphingolipids that play critical roles in various cellular processes. One of their key functions is in cellular recognition and adhesion.
Based on development of various methodologies for isolation and characterization of glycosphingolipids (GSLs), we have identified a number of GSLs with globo-series or lacto-series structure. Many of them are tumor-associated or developmentally-regulated antigens. The major question arose, what are their functions in cells and tissues?
Globoside is a tetrasaccharide glycolipid that corresponds to the P blood group antigen and is involved in the expression of certain cell surface markers on red blood cells. AI generated definition based on: Stem Cell Research, 2009
Globosides are a sub-class of the lipid class glycosphingolipid [1] with three to nine sugar molecules as the side chain (or R group) of ceramide. The sugars are usually a combination of N -acetylgalactosamine, D -glucose or D -galactose.
Globosides and gangliosides (the most complex) are complex glycosphingolipids that contain a ceramide and an oligosaccharide fragment. They are particularly abundant at nerve endings and at specific hormone receptor sites on cell surfaces and therefore play an important role in molecular recognition.
Globosides are GSLs that contain multiple sugar moieties. You might find these chapters and articles relevant to this topic. Arnold E. Stütz, Tanja M. Wrodnigg, in Advances in Carbohydrate Chemistry and Biochemistry, 2016.
