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Homodimeric glial cell line-derived neurotrophic factor (GDNF)-family ligands (GFLs) activate RET tyrosine kinase (TK) by first binding their cognate GDNF-family receptor-α (GFRα) receptors.
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Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. [5] GDNF is a small protein that potently promotes the survival of many types of neurons. [6] It signals through GFRα receptors, particularly GFRα1.
8 wrz 2020 · Glial cell line–derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons.
28 mar 2022 · Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation.
Keywords: astrocytes, brain-derived neurotrophic factor, cell migration, glial cell line-derived neurotrophic factor, glial interaction, Schwann cells, trigeminal nerve. Abstract. The trigeminal root entry zone is the zone at which the myelination switches from peripheral Schwann cells to central oligodendrocytes.
12 gru 1998 · The discovery of glial cell line-derived neurotrophic factor (GDNF) as a neurotrophic factor for midbrain dopaminergic neurons was a hallmark in the search for novel molecules that may have relevance in the treatment of neurodegenerative diseases, as e.g., Parkinson’s disease (PD; Lin et al., 1993).
21 maj 1993 · Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-β superfamily. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high ...
