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13 wrz 2022 · GATA4 is linked to a pathway through which DDR leads to senescence. GATA4 can not only cause cell senescence but also plays a role in cardiovascular development and disease. For example, overexpression of GATA4 can lead to cardiac hypertrophy and heart failure (Zhou et al., 2012).
22 paź 2018 · Among them, GATA4 has the earliest unique function in the heart, as its inactivation in the mouse leads to embryonic lethality between E8.5 and E10.5 due to severe defects in ventral body patterning and a lack of pericardial cavity and heart tube (Kuo et al., 1997; Molkentin et al., 1997).
10 sty 2023 · This study found that regional epithelial expression of the transcription factor GATA4 controls bacterial colonization and inflammatory tissue immunity in the proximal small intestine by regulating retinol metabolism and luminal IgA.
24 wrz 2014 · GATA4 chromatin occupancy changes markedly between fetal and adult heart, with a limited binding sites overlap. Cardiac stress restored GATA4 occupancy to a subset of fetal sites, but many...
GATA4 is a prognostic marker in Ovary serous cystadenocarcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.
2 maj 2018 · GATA4 induces the angiogenic factors VEGFA and VEGFC, by directly binding to the promoter and enhancing transcription. The knockdown of GATA4 attenuates the development of collagen-induced...
2 paź 2024 · GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2. Among its related pathways are Gene expression (Transcription) and Cardiac conduction.
