Search results
GATA4 is a prognostic marker in Ovary serous cystadenocarcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.
22 paź 2018 · The conditional deletion of Gata4 (using Wt1 Cre) in the coelomic epithelium results in a complete absence of genital ridge formation and a failure to initiate testis and ovary development (Hu et al., 2013). Hence, GATA4 is an early and essential driver of gonad formation in both male and female embryos.
2 maj 2018 · GATA4 induces the angiogenic factors VEGFA and VEGFC, by directly binding to the promoter and enhancing transcription. The knockdown of GATA4 attenuates the development of collagen-induced arthritis (CIA) and prevents RA-augmented angiogenesis in vivo, which are accompanied with decreased VEGF level.
18 wrz 2024 · Title: Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer.
8 sie 2022 · GATA4 (GATA-binding protein 4), a zinc finger–containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene have been reported in human heart defects.
It demonstrates that the interaction between the two factors is required for sex determination while GATA4 alone is required for female differentiation after sex determination [60]. In our serial profile, GATA4 was found to regulate both calcium signaling and the integrin-linked kinase (ILK) signaling pathway in the indifferent gonad after ...
9 wrz 2015 · GATA4 accumulates in multiple tissues, including the aging brain, and could contribute to aging and its associated inflammation. The non-senescent state is maintained by inhibitory barriers that prevent cell cycle arrest and inflammation.
