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22 paź 2018 · In recent years, a number of examples of pioneer activity have been reported for GATA transcription factors. Acting as a priming factor, GATA4 binds closed chromatin prior to hepatocyte specification and promotes liver-specific gene expression ( Bossard and Zaret, 1998 ; Cirillo et al., 2002 ).
13 kwi 2017 · In this review, we focus on the hematopoietic factors GATA1 and GATA2 and the contributions of their alterations in benign and malignant blood diseases. GATA1 is an X-linked gene that encodes a DNA binding protein with two zinc fingers and a transactivation domain.
30 cze 2021 · GATA4 gene regulatory variants were identified by comparing to human GATA4 gene (NG_008177.2). Dual-luciferase reporter assay. GATA4 gene promoter (971 bp, from − 932 bp to + 39 bp) was generated by PCR and subcloned into the SacI and Hind III sites of pGL3-basic, a luciferase reporter vector.
2 paź 2024 · GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2. Among its related pathways are Gene expression (Transcription) and Cardiac conduction.
GATA4 is a prognostic marker in Ovary serous cystadenocarcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.
By screening a human heart cDNA library, Huang et al. (1995) isolated a full-length cDNA clone for GATA4. Northern blot analysis revealed that the 4.4-kb transcript was more highly expressed in adult heart than in fetal heart. They concluded that GATA4 may regulate a set of cardiac-specific genes and play a crucial role in cardiogenesis.
18 wrz 2024 · Title: GATA4 regulates the transcription of MMP9 to suppress the invasion and migration of breast cancer cells via HDAC1-mediated p65 deacetylation. Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNalpha production.
