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22 paź 2018 · GATA4 is primarily associated with sex determination and gonadal development (Viger et al., 1998). The conditional deletion of Gata4 (using Wt1 Cre) in the coelomic epithelium results in a complete absence of genital ridge formation and a failure to initiate testis and ovary development (Hu et al., 2013). Hence, GATA4 is an early and essential ...
13 kwi 2017 · In this review, we focus on the hematopoietic factors GATA1 and GATA2 and the contributions of their alterations in benign and malignant blood diseases. GATA1 is an X-linked gene that encodes a DNA binding protein with two zinc fingers and a transactivation domain.
30 cze 2021 · GATA4 gene regulatory variants were identified by comparing to human GATA4 gene (NG_008177.2). Dual-luciferase reporter assay GATA4 gene promoter (971 bp, from − 932 bp to + 39 bp) was generated by PCR and subcloned into the SacI and Hind III sites of pGL3-basic, a luciferase reporter vector.
2 paź 2024 · GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2. Among its related pathways are Gene expression (Transcription) and Cardiac conduction.
13 wrz 2022 · Transcription factor GATA4, which plays an important role in SASP and cell aging regulation, was identified when studying the influencing factors of cell aging. GATA4 protein, but not its mRNA, accumulates during cell senescence due to increased protein stability.
Specific antibody deficiency is a primary antibody deficiency characterized by normal levels of immunoglobulins and subclasses, recurrent sinopulmonary infections, and poor response to polysaccharide antigens after vaccination.
GATA4 deletions appear to be present in a significant number of CHD patients, especially those with septal defects, persistent left superior vena cava, pulmonary artery abnormalities, and extracardiac findings. GATA4 screening seems to be more effective when directed to these CHDs.
