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22 paź 2018 · Here, we briefly discuss the molecular hallmarks and mode of action of GATA proteins, review the different developmental systems in which GATA members have been implicated and link these findings to human disease. Fig. 1. The GATA family of proteins.
30 mar 2023 · Inherited or de novo germ line heterozygous mutations in the gene encoding the transcription factor GATA2 lead to its deficiency. This results in a constellation of clinical features including nontuberculous mycobacterial, bacterial, fungal, and human papillomavirus infections, lymphedema, pulmonary alveolar proteinosis, and myelodysplasia.
13 kwi 2017 · In this review, we focus on the hematopoietic factors GATA1 and GATA2 and the contributions of their alterations in benign and malignant blood diseases. GATA1 is an X-linked gene that encodes a DNA binding protein with two zinc fingers and a transactivation domain.
28 mar 2012 · The present results offer insights into the mechanism by which GATA4 deficiency attenuates postgonadectomy adrenocortical neoplasia. In theory, GATA4 could promote tumor initiation, sex steroidogenic differentiation, or tumor cell growth/survival.
13 wrz 2022 · Transcription factor GATA4, which plays an important role in SASP and cell aging regulation, was identified when studying the influencing factors of cell aging. GATA4 protein, but not its mRNA, accumulates during cell senescence due to increased protein stability.
6 lut 2014 · GATA2 deficiency has a broad phenotype encompassing immunodeficiency, MDS/AML, pulmonary disease, and vascular/lymphatic dysfunction. Early genetic diagnosis is critical to direct clinical management, prophylaxis, transplantation, and family screening.
GATA4 deletions appear to be present in a significant number of CHD patients, especially those with septal defects, persistent left superior vena cava, pulmonary artery abnormalities, and extracardiac findings. GATA4 screening seems to be more effective when directed to these CHDs.
