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  1. Gas exchange in the lungs takes place in alveoli, which are tiny air sacs surrounded by networks of capillaries. The pulmonary artery carries deoxygenated blood from the heart to the lungs, where it travels through pulmonary capillaries, picking up oxygen and releasing carbon dioxide.

  2. 1.1 Gas Exchange Gas exchange is the process by which atmospheric oxygen (O 2) is transferred from the alveolar gas into the bloodstream and carbon dioxide (CO 2) from the blood-stream into the alveolar gas phase. CO 2 is then eliminated into the atmosphere by ventilation. Gas exchange occurs at the level of the transitional and respiratory

  3. BACKGROUND: The principal function of the lung is gas exchange requiring adequate ventilation and perfusion at the level of the alveoli. The efficiency of gas exchange is depending on the distributions of regional ventilation (V) and pulmonary blood flow (Q) and their correlation.

  4. The lungs are the site of gas exchange of the body with the environment, i.e., of uptake of O 2 and output of CO 2 (only about 1 % of the gas exchange in man takes place across body skin). The human lung airways (Fig. lO1.1a) represent a tree-like structure, formed by repetitive branching of bronchi down

  5. The mechanisms for the exchange of O 2 and CO2 between the alveolar gas and pulmonary capillary blood are the subject of this chapter. These passive mechanisms can be influenced by outside factors, such as gravity and barometric pressure, and they are altered by most respiratory diseases.

  6. Two important aspects of gas exchange in the lung are ventilation and perfusion. Ventilation is the movement of air into and out of the lungs, and perfusion is the flow of blood in the pulmonary capillaries.

  7. gas exchange organs, with air or water as external respiratory medium, is considered. Then the internal (tissue) gas exchange is discussed, using simple models for interaction of blood flow and diffusion.

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