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1 gru 2020 · Fluoride causes alterations in the thyroid cells, e.g. mitochondrial swelling and disintegration, damage RNA and DNA and subsequently impede their repair processes, suppress glycolysis and endocrine functions in follicular cell.
12 lip 2021 · Fluoride has varying effects on cells depending upon cell type and concentration. At low concentration, it causes cell proliferation (anabolic effects) and inhibits at higher concentration. Furthermore, it acts as an enzyme inhibitor Enolase (glycolytic pathway), Phosphatase, and inhibits protein synthesis.
9 mar 2020 · Recently, there has been renewed concern in the public sector as to whether fluoride is safe at the current exposure levels. In this review, we will focus on the impact of fluoride at the chemical, cellular, and multisystem level, as well as how organisms defend against fluoride.
26 maj 2022 · Despite being present in only trace amounts in the body (∼2.6 g), fluoride has a significant nutritional and public health impact due to its role in the mineralization of hard tissues including bones and teeth .
Ingested fluoride forms hydrofluoric acid in the stomach. In this form, fluoride crosses cell membranes and then binds with calcium and interferes with various enzymes. Fluoride is excreted through urine. Fluoride exposure limits are based on urine testing, which is used to determine the human body's capacity for ridding itself of fluoride. [69 ...
8 mar 2022 · Despite being present in only trace amounts in the body (∼2.6 g), fluoride has a significant nutritional and public health impact due to its role in the mineralization of hard tissues including bones and teeth (1).
There are several known mechanisms which lead to structural brain damage caused by the excessive intake of fluorine. This element is able to cross the blood-brain barrier, and it accumulates in neurons affecting cytological changes, cell activity and ion transport (e.g. chlorine transport).
