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RNA polymerase II (Pol II) core promoters are specialized DNA sequences at transcription start sites of protein-coding and non-coding genes that support the assembly of the transcription machinery and transcription initiation.
26 cze 2018 · RNA polymerase II (Pol II) core promoters are specialized DNA sequences at transcription start sites of protein-coding and non-coding genes that support the assembly of the transcription...
3 paź 2024 · Upon interaction between the bait and prey RNAs, the m26 activator becomes tethered to the promoter region of the reporter gene to activate its expression. These simple yet sophisticated low-throughput techniques collectively advanced our understanding of specific RRIs in gene regulation.
RNA polymerase II (Pol II) core promoters are specialized DNA sequences at transcription start sites of protein-coding and non-coding genes that support the assembly of the transcription machinery and transcription initiation.
The initiation of messenger RNA synthesis by RNA polymerase II is regulated by a collection of cis-acting DNA elements. The core promoter, which is typically found ∼40 bp upstream and downstream of the transcription start site, plays a crucial role in the recruitment and positioning of the basic transcription machinery.
18 wrz 2024 · Besides, to test the effect of promoter DNA methylation on transcriptional memory, we replaced the CpG sites on the TRE3G promoter with GG or CC and inserted it into ECT2 site using the CRISPR/Cas9 technology (sgRNAnology (sgRNA inserte).
22 mar 1996 · Unregulated transcription initiation at many prokaryotic promoters requires only an RNA polymerase holoenzyme, consisting of four core subunits and a dissociable σ factor . It is the σ factor that interacts directly with the promoter DNA.
