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1 lip 2020 · To gain insight into the spatiotemporal organization of the genome, we use high-density photoactivated localization microscopy and deep learning to obtain temporally resolved super-resolution images of chromatin in living cells.
22 lut 2017 · Chromatin is a DNA-protein polymer, which consists of DNA, structural proteins, non-structural proteins and RNA. During interphase, chromatin encodes the information necessary to maintain the primary functions of the cells.
4 lis 2023 · In this review, we describe recent imaging techniques to study the dynamic organization of chromatin at high spatiotemporal resolution. We also discuss recent findings, elucidated by these techniques, on the chromatin landscape during different cellular processes, with an emphasis on the DNA damage response.
Robust cellular function requires proteins to access genetic information in an ever-shifting landscape of structures. Chromatin (see Glossary), the chromosomal DNA polymer wrapped around nucleosomes, is dynamically remodeled during replication and transcription.
24 mar 2021 · This chapter contains an introduction to the organization and function of chromatin and provides a basis for understanding its role in regulating the cellular function of DNA sequences.
7 wrz 2023 · The structure of chromatin is intimately linked to its function in information storage and gene expression, and numerous approaches across genomics and imaging have been developed to probe...
22 lut 2016 · Painting a Clearer Picture of Chromatin. Elucidating chromatin’s 3D shape is critical to understanding its function, but the fine structure of chromatin domains remains poorly resolved. In a recent report in Nature, Boettiger et al., 2016. visualize chromatin in super-resolution, gaining unprecedented insight into chromatin architecture. Main Text.
