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3 lis 2020 · While focusing on restoring heart muscle and replenishing lost coronary vessels is clearly important, mounting evidence suggests that achieving full regeneration will require fibroblast, immune, conductive, and nervous cell contributions to the regenerative process.
27 cze 2018 · The epicardium is essential for muscle regeneration in the zebrafish model of innate heart regeneration, and the epicardium also participates in fibrotic responses in mammalian hearts.
6 kwi 2021 · The conditional ablation of ERBB2 in embryonic or neonatal mouse CMs leads to reduced proliferation. Consistently, genetic activation of ERBB2 significantly improves cardiac function post-MI, indicating that this pathway can be exploited as a viable target for heart regeneration (D'Uva et al. 2015).
In this review, we focus on the roles of fibroblasts, immune cells, conduction system and nervous system cell populations during heart development and we consider the latest evidence supporting a function for these diverse lineages in contributing to regeneration following heart injury.
25 cze 2020 · Indeed, specific deletion of Fgfr1 and Fgfr2 in CECs in mice impaired cardiac functional recovery and diminished vascular remodelling after MI, implicating a beneficial role for this pathway in...
When the synthetic miR mimics miR-199a-3p and miR-590–3p were transiently delivered by using a lipid-based vehicle (i.e. RNAiMAX), significantly increased CM proliferation was observed, as well as decreased cardiac scar formation and increased cardiac function in the short term .
23 cze 2021 · In this review, we summarize recent advances from the zebrafish cardiovascular research community with novel insight into the mechanisms associated with endogenous cardiovascular repair and regeneration, which may be of benefit to inform future strategies for patients with cardiovascular disease.
