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3 lis 2020 · A pro-regenerative chemical and mechanical microenvironment, mediated principally by fibroblast, macrophage and nervous system signalling, result in removal of scar tissue, cardiomyocyte division to replace lost muscle tissue, and generation of new vasculature.
6 kwi 2021 · The MAPK signaling pathway is a classical kinase cascade pathway activated by growth factors such as fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF), and it regulates cell proliferation, differentiation, and survival, as well as playing a key role in cardiovascular diseases (Muslin 2008).
25 sie 2021 · Upregulation of both receptors and PDGF-B is noted at day 7 in a mouse ischemic reperfusion model, with blockage of the PDGFRβ causing leaky blood vessels, while blocking the PDGFRα significantly decreases collagen deposition in the infarct, both impairing healing (Zymek et al., 2006).
18 lis 2020 · We show that during heart development, the myocardial vascular endothelial growth factor–B transgene promotes the formation of endocardium-derived coronary vessels, and after myocardial infarction, vascular endothelial growth factor–B provides structural and functional rescue of cardiac tissue.
2 lut 2021 · Epicardial cells can further give rise to cardiac fibroblasts and coronary vascular smooth muscle cells through epithelial-to-mesenchymal transition and provide structural support for the heart (Zhou et al., 2008; Cai et al., 2008).
29 lis 2016 · Numerous studies have been completed on heart development with respect to finding ways to regenerate functional cardiac muscle tissue after myocardial damage has resulted from acute myocardial infarction (AMI) or related cardiac disease processes.
6 kwi 2023 · In the present study, we defined the cellular and transcriptional landscape of cardiac recovery using snRNA-seq. We compared non-diseased donor controls to patients with HF who experienced...
