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28 wrz 2023 · SARS-CoV-2 induced a robust inflammatory response in cultured macrophages and human atherosclerotic vascular explants with secretion of cytokines known to trigger cardiovascular events.
12 lip 2021 · This review comprehensively describes several possibly proven and hypothetical molecular mechanisms in cellular fractions of heart and vessel that are likely to occur during SARS-CoV-2 infection, in particular, causing heart failure and injuries to the vascular beds, mediated by host components in terms of vascular leakage and thrombotic events.
11 maj 2023 · Data point to pericytes as the primary target of SARS-CoV-2 in the heart. Infection of pericytes can account for the observed pericyte and endothelial cell death, innate immune response, and immunothrombosis commonly observed in COVID-19 hearts.
10 paź 2022 · Clearance of the K287T virus from most infected cells by 7 dpi leads to a lower immune-mediated cytotoxicity, which correlates with lack of cardiac injury.
23 lis 2022 · Studies focusing on patients presenting cardiomyopathic symptoms showed that parvovirus B19, adenovirus, CVB3, Epstein–Barr virus, human cytomegalovirus and human herpesvirus 6 are primarily detected in heart samples exhibiting signs of infection (Figure 2).
30 mar 2020 · This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction.
16 mar 2022 · We discovered that spike, when expressed on the plasma membrane, is primed by furin and triggers fusion of the SARS-CoV-2-infected cells with neighboring cells expressing ACE2 (Fig. 2).
