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  1. 24 wrz 2020 · Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease. Cardiovascular...

  2. 13 lis 2017 · Here, we determine the healthy human heart proteome by measuring 16 anatomical regions and three major cardiac cell types by high-resolution mass spectrometry-based proteomics.

  3. 14 wrz 2021 · Human heart (patho)physiology is now widely studied using human pluripotent stem cells, but the immaturity of derivative cardiomyocytes has largely limited disease modeling to conditions associated with mutations in cardiac ion channel genes.

  4. 28 lut 2022 · In this review, we discuss recent advances in biosensing platforms for the measurement of contractile functions of in vitro cardiac models, including single cardiomyocytes, 2D monolayers of...

  5. 1 sty 2011 · In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics.

  6. 23 sie 2021 · This Review provides an overview of the current three main approaches for modeling heart physiology and disease in vitro: cardiac specification models, engineered heart tissues/organoids and self-organizing embryonic and cardiac-specific organoids.

  7. 1 sie 2004 · Introducing these changes into cardiac cell models succeeds in reproducing failure of repolarization and multiple reexcitations of the kind that generate major arrhythmia and in showing that the major factor involved is the changes in calcium balance.

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