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  1. 24 wrz 2020 · Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease.

  2. 14 wrz 2021 · Human heart (patho)physiology is now widely studied using human pluripotent stem cells, but the immaturity of derivative cardiomyocytes has largely limited disease modeling to conditions associated with mutations in cardiac ion channel genes.

  3. 14 cze 2023 · Introduction. The healthy contraction of the cardiac muscle is initiated by an action potential (AP) generated in the sinoatrial node (SA-node). From the SA-node, the AP propagates as an...

  4. 24 sie 2022 · SeisWind® 3D is designed to offer an efficient data acquisition footprint with the highest resolution to enable detailed ground modelling and interpretation of near surface geology for the safe development of offshore projects.

  5. 1 maj 2024 · The resulting phenotypes resembled those of acute myocardial infarction (AMI), characterized by cardiac cell death, biomarker secretion, functional deficits, alterations in calcium ion handling...

  6. 1 sty 2011 · Multiscale heart modelling is arguably further advanced than any other organ system; in particular the modelling of cardiac contraction, electrical excitation and metabolism at the cellular scale provides perhaps the most sophisticated examples of modelling frameworks currently available.

  7. 23 sie 2021 · This Review provides an overview of the current three main approaches for modeling heart physiology and disease in vitro: cardiac specification models, engineered heart tissues/organoids and self-organizing embryonic and cardiac-specific organoids.

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