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1 maj 2024 · The resulting phenotypes resembled those of acute myocardial infarction (AMI), characterized by cardiac cell death, biomarker secretion, functional deficits, alterations in calcium ion...
8 sie 2024 · In this study, we have developed a 3D heart-on-a-chip model using iPSCs, fibroblasts, and endothelial cells, designed to mimic the anatomical structure of cardiac tissue.
11 lip 2023 · In the study here, we developed a fully vascularized and perfusable cardiac microtissue (MT) on-chip by integrating pre-vascularized cardiac MTs with an external vascular network formed by self-organization of human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) and human brain vascular pericytes (HBVPs) in fibrin hydrogel ...
13 mar 2024 · Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of...
Our results demonstrate that primitive MΦs enhance vascularized cardiac tissue performance via two primary mechanisms: direct cellular interaction and the release of matrix metalloproteinases (MMPs) alongside other pro-angiogenic and cardiac-related cytokines, resulting in long-term perfusable tissues with increased cellular viability and ...
6 sty 2022 · In fundamental cardiovascular research, in silico cardiovascular models have mainly been used to translate changes in cellular physiology observed in vitro or in animal models to cellular changes in human cells and whole-organ human clinical phenotypes.
16 lut 2023 · In this review series we cover the current state of knowledge in the field of cardiovascular organoids and 3D cell culture models. In Modelling heart diseases on chip: advantages and future opportunities , Mourad et al 10 discuss the current state of heart-on-a-chip technology.
