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13 mar 2024 · Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of cardiac...
24 wrz 2020 · Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease.
29 kwi 2024 · The FUCCI system allows the assessment of cycling and non-cycling cells, but the approach is limited by the rare activation of cycling cardiomyocytes in adult hearts after cardiac injury and the inability to label daughter cells to identify endoreplicative and authentic cell division in vivo.
3 dni temu · Cardiovascular disease (CVD) remains a global economic burden even in the 21st century with 85% of deaths resulting from heart attacks. Despite efforts in reducing the risk factors, and enhancing pharmacotherapeutic strategies, challenges persist in early identification of disease progression and functional recovery of damaged hearts. Targeting mitochondrial dysfunction, a key player in the ...
6 kwi 2021 · The cyclin B1-CDC2 complex is the key regulator of the G2/M-phase transition in CMs, and its overexpression re-initiates cell division of adult cardiomyocytes in vitro (Bicknell et al. 2004).
5 mar 2021 · In this Review, we discuss the diverse roles the ECM plays during cardiac development, from the formation of the linear heart tube through to heart maturation, focussing on how ECM modification and turnover are emerging as central themes in regulating distinct aspects of morphogenesis.
24 sie 2022 · SeisWind® 3D is an evolution of Fugro’s UUHR seismic service that consists of eight solid custom specification digital streamers, with proprietary sources and decimetre accuracy in-sea positioning systems.
