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13 mar 2024 · Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of...
24 wrz 2020 · Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease. Cardiovascular...
28 wrz 2018 · Single-cell analyses have identified early cardiac progenitor cell types, providing new insights into cell heterogeneity and developmental trajectories of cardiac cells as the heart develops.
6 kwi 2021 · Conditional knockout of Gata4 leads to the loss of regenerative ability in neonatal mice, and overexpression of Fgf16 via AAV9 in the Gata4-deficient heart partially rescues cardiac hypertrophy and improves heart function after injury (Yu et al. 2016).
14 maj 2020 · Recent advances in single-cell sequencing have provided an unprecedented view of the diversity of the cell subtypes in health and disease. We performed large-scale single-nucleus RNA sequencing to define the cellular and transcriptional diversity in the 4 chambers of the normal human heart.
5 mar 2021 · In this Review, we discuss the diverse roles the ECM plays during cardiac development, from the formation of the linear heart tube through to heart maturation, focussing on how ECM modification and turnover are emerging as central themes in regulating distinct aspects of morphogenesis.
29 kwi 2024 · The FUCCI system allows the assessment of cycling and non-cycling cells, but the approach is limited by the rare activation of cycling cardiomyocytes in adult hearts after cardiac injury and the inability to label daughter cells to identify endoreplicative and authentic cell division in vivo.
