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1 paź 2021 · Myocardial infarction and cardiac pressure overload induce regional patterns of cycling cardiomyocytes. Mechanistically, cardiomyocyte cell cycle activity requires the Hippo pathway effector...
27 sty 2021 · First, residual cardiomyocytes in damaged hearts re-enter the cell cycle to acquire the proliferative capacity by the modifications of cell cycle-related genes or regulation of growth-related...
13 mar 2024 · Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of...
Chemical inhibition of Tgf-β and Wee1 made CDK1 and cyclin B dispensable. These findings reveal a discrete combination of genes that can efficiently unlock the proliferative potential in cells that had terminally exited the cell cycle. Keywords: Heart, Cardiomyocyte, Cell Division, Cyclin, CDK, Cell Cycle, Regeneration. INTRODUCTION
Our results demonstrate that primitive MΦs enhance vascularized cardiac tissue performance via two primary mechanisms: direct cellular interaction and the release of matrix metalloproteinases (MMPs) alongside other pro-angiogenic and cardiac-related cytokines, resulting in long-term perfusable tissues with increased cellular viability and ...
6 kwi 2021 · Here, we review both the classical and recent literature on the molecular and cellular mechanisms underlying heart regeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes to replenish their massive loss after myocardial infarction or ventricular resection.
In combination with functional studies, such as fluorescence imaging, exciting insights into cardiac autoregulatory processes at nano-to-micro scales are starting to emerge.
