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22 mar 2018 · Here, we report a combination of cell-cycle regulators that induce stable cytokinesis in adult post-mitotic cells. We screened cell-cycle regulators expressed in proliferating fetal cardiomyocytes and found that overexpression of cyclin-dependent kinase 1 (CDK1), CDK4, cyclin B1, and cyclin D1 efficiently induced cell division in post-mitotic ...
1 paź 2021 · Myocardial infarction and cardiac pressure overload induce regional patterns of cycling cardiomyocytes. Mechanistically, cardiomyocyte cell cycle activity requires the Hippo pathway effector...
The FUCCI-Tg has identified cardiomyocyte “mitotic” cell cycle arrest at the G1/S restriction point (Fig. 3). Over 95% of CMs express mKO and AzG by postnatal day 21 indicative of seized cycling.
27 sty 2021 · First, residual cardiomyocytes in damaged hearts re-enter the cell cycle to acquire the proliferative capacity by the modifications of cell cycle-related genes or regulation of...
19 lis 2019 · Different factors including other miRNA (e.g. miR-302, miR-199a-3p and miR-590-3p) can promote re-entry of mature CMs into the cell cycle and induce cardiac regeneration by targeting genes of various signalling pathways.
29 kwi 2024 · The FUCCI system allows the assessment of cycling and non-cycling cells, but the approach is limited by the rare activation of cycling cardiomyocytes in adult hearts after cardiac injury and the inability to label daughter cells to identify endoreplicative and authentic cell division in vivo.
30 wrz 2016 · Among the cell-cycle-associated miRNAs, miR499, miR302-367, miR590, miR199a, miR204, and miR17-29 positively regulate cardiomyocyte cell cycle, while miR1, miR15, miR16, miR26a, miR29a, miR30a, 34a, miR133a, and miR141 negatively regulate cell cycle by modulating the expression of different cyclins (cyclins D, E, A, and B) and cyclin-dependent ...
