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1 paź 2021 · We found ProTracer provides a high spatiotemporal resolution for cardiomyocyte-specific cell-cycle activity in the adult heart during cardiac homeostasis and after injuries.
6 kwi 2021 · Here, we review both the classical and recent literature on the molecular and cellular mechanisms underlying heart regeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes to replenish their massive loss after myocardial infarction or ventricular resection.
27 sty 2021 · First, residual cardiomyocytes in damaged hearts re-enter the cell cycle to acquire the proliferative capacity by the modifications of cell cycle-related genes or regulation of...
22 mar 2018 · We screened cell-cycle regulators expressed in proliferating fetal cardiomyocytes and found that overexpression of cyclin-dependent kinase 1 (CDK1), CDK4, cyclin B1, and cyclin D1 efficiently induced cell division in post-mitotic mouse, rat, and human cardiomyocytes.
5 dni temu · FHL2 (Four-and-a-half LIM domain protein 2) is a crucial factor involved in cardiac morphogenesis, the process by which the heart develops its complex structure. It is expressed in various tissues during embryonic development, including the developing heart, and has been shown to play important roles in cell proliferation, differentiation, and migration. FHL2 interacts with multiple proteins ...
25 mar 2022 · In this review, we discuss molecular mechanisms of cellular senescence, explore how cellular senescence of different cardiac cell types (including cardiomyocytes, cardiac endothelial cells, cardiac fibroblasts, vascular smooth muscle cells, and valve interstitial cells) can lead to CVD, and highlight potential therapeutic approaches that target ...
29 kwi 2024 · Overexpression of TBX20 or TBX6 in adult mouse heart induces cardiomyocyte proliferation by regulating the expression of multiple cell cycle regulators, TBX20 overexpression also promotes cardiac repair and improves heart function in mouse after MI [61, 192].
