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27 sty 2021 · First, residual cardiomyocytes in damaged hearts re-enter the cell cycle to acquire the proliferative capacity by the modifications of cell cycle-related genes or regulation of...
1 paź 2021 · We found ProTracer provides a high spatiotemporal resolution for cardiomyocyte-specific cell-cycle activity in the adult heart during cardiac homeostasis and after injuries.
Intramyocardial delivery of the cell cycle regulators resulted in improved cardiac function after injury relative to controls, even when the cell-cycle regulators were delivered after partial consolidation of the scar tissue induced by coronary ligation.
6 kwi 2021 · Here, we review both the classical and recent literature on the molecular and cellular mechanisms underlying heart regeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes to replenish their massive loss after myocardial infarction or ventricular resection.
24 wrz 2020 · Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease. Cardiovascular...
29 kwi 2024 · Overexpression of TBX20 or TBX6 in adult mouse heart induces cardiomyocyte proliferation by regulating the expression of multiple cell cycle regulators, TBX20 overexpression also promotes cardiac repair and improves heart function in mouse after MI [61, 192].
17 mar 2022 · A complimentary approach to cell-cycle marker analysis is to infer complete cardiomyocyte cell division by estimating the associated increase in total cardiomyocyte numbers in the entire heart, also known as “endowment.”
