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1 paź 2021 · We found ProTracer provides a high spatiotemporal resolution for cardiomyocyte-specific cell-cycle activity in the adult heart during cardiac homeostasis and after injuries.
27 sty 2021 · First, residual cardiomyocytes in damaged hearts re-enter the cell cycle to acquire the proliferative capacity by the modifications of cell cycle-related genes or regulation of growth-related...
29 kwi 2024 · Overexpression of TBX20 or TBX6 in adult mouse heart induces cardiomyocyte proliferation by regulating the expression of multiple cell cycle regulators, TBX20 overexpression also promotes cardiac repair and improves heart function in mouse after MI [61, 192].
6 kwi 2021 · Here, we review both the classical and recent literature on the molecular and cellular mechanisms underlying heart regeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes to replenish their massive loss after myocardial infarction or ventricular resection.
28 wrz 2018 · Key points. Clonal analysis shows that two myocardial cell lineages, which segregate early at gastrulation, form the heart, with cell sublineages contributing to the arterial and venous poles,...
21 sty 2022 · Transient expression of the 4 cell cycle factors using TNNT2-4Fpolycistronic-NIL improves cardiac function, reduces scar size, and induces cardiomyocyte proliferation in a porcine model of heart failure.
27 sty 2021 · These findings provide the theoretical basis of targeting cellular fate plasticity to induce cardiomyocyte proliferation or formation, and also provide the clues for stimulating heart repair after injury.
