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Quantitation of cell cycle status of myocyte populations can be used in combination with DNA labeling to correlate cell cycle progression with DNA synthesis versus DNA damage, and most importantly in vivo labeling is assessed in the adult mammalian heart. The findings presented herein demonstrate not only the straightforward simplicity and ...
1 paź 2021 · We found ProTracer provides a high spatiotemporal resolution for cardiomyocyte-specific cell-cycle activity in the adult heart during cardiac homeostasis and after injuries.
27 sty 2021 · First, residual cardiomyocytes in damaged hearts re-enter the cell cycle to acquire the proliferative capacity by the modifications of cell cycle-related genes or regulation of...
31 maj 2022 · We clearly identified the three major cell types of the cardiac vascular niche: fibroblasts (Dcn +, Col1a1 +, Pdgfrα +), endothelial cells (Kdr +, Pecam1 +), and mural cells (Rgs5 +, Kcnj8...
29 kwi 2024 · The FUCCI system allows the assessment of cycling and non-cycling cells, but the approach is limited by the rare activation of cycling cardiomyocytes in adult hearts after cardiac injury and the inability to label daughter cells to identify endoreplicative and authentic cell division in vivo.
6 kwi 2021 · Here, we review both the classical and recent literature on the molecular and cellular mechanisms underlying heart regeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes to replenish their massive loss after myocardial infarction or ventricular resection.
Intramyocardial delivery of the cell cycle regulators resulted in improved cardiac function after injury relative to controls, even when the cell-cycle regulators were delivered after partial consolidation of the scar tissue induced by coronary ligation.
